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Control Systems. 5 cr. hrs.

Provides an introduction to the principles of control systems theory for biomedical engineers. Mathematical techniques to characterize and design control systems will be studied in the context of physiological, bioelectrical, biochemical and biomechanical systems. Topics include frequency and time-domain modeling of physiological control systems, feedback, stability, steady-state error, design, root-locus, state-space techniques, and nonlinear control. Simulation using MATLAB and Simulink will be used to provide hands-on experience in the design of biomedical control systems.

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Tissue Engineering. 3 cr. hrs.

This course is an introduction to the field of tissue engineering. It is rapidly emerging as a therapeutic approach to treating damaged or diseased tissues in the biotechnology industry. In essence, new and functional living tissue can be fabricated by delivering cells, scaffolds, DNA, proteins, and/or protein fragments at surgery. This course will cover the advances in the fields of cell biology, molecular biology, material science and their relationship towards developing novel “tissue engineered” therapies.

This course is an introduction to the current status of, practice and advances in tissue engineering, the biomedical engineering discipline that applies science and technology to develop novel means for replacing damaged and/or diseased tissues of the body. The course focuses both on fundamental aspects of the field, specifically, cells, materials, biochemical and biophysical stimuli, which are pertinent to new tissue formation, and on select application examples, specifically, bone, cartilage, skin, and vascular tissues. Strategies used to address current challenges, pursue emerging opportunities and explore new directions are reviewed and discussed.

The goal of this course is for students to be able to give a presentation on a product of their choice related to tissue engineering. The lectures, discussions, and design exercises are designed to help you complete each of the following aspects of the project: (1) Motivation/Market Need, (2) Disease/Condition/Anatomy, (3) Design Specifications and Testing Methods, (4) Scientific Basis of Product Technology and (5) Ethical Issues / FDA. There is a final oral presentation at the end of the course.

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Design of Machine Elements. 3 cr. hrs.

Detailed design of structural elements, shafts, gears, bearings, and other machine elements. Laboratory activities which cover the theoretical and experimental analysis of machine elements. 3 hrs. lec., 2 hrs. lab.

Detailed design of structural elements, shafts, gears, bearings, and other machine elements. Laboratory activities which cover the theoretical and experimental analysis of machine elements. 3 hrs. lec., 2 hrs. lab.

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Engineering Systems. 3 cr. hrs.

Focuses on the modeling and solution of physical systems including translational and rotational mechanical systems, mass balance systems (fluids, chemical), thermal systems and electrical systems. Analytic solution techniques stress the universality of the mathematics for all systems. Computer solutions using MatLab and Simulink are used to further investigate the linear system behavior and to introduce non-linear system behavior.

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Microcontroller & Microprocessor

Introduction to 8085A CPU architecture-register organization, addressing modes and their features. Software instruction set and Assembly Language Programming. Pin description and features. Instruction cycle, machine cycle, Timing diagram. Hardware Interfacing: Interfacing memory, peripheral chips (IO mapped IO & Memory mapped IO). Interrupts and DMA. Peripherals: 8279, 8255, 8251, 8253, 8237, 8259, A/D and D/A converters and interfacing of the same. Typical applications of a microprocessor. 16 bit processors: 8086 and architecture, segmented memory has cycles, read/write cycle in min/max mode. Reset operation, wait state, Halt state, Hold state, Lock operation, interrupt processing. Addressing modes and their features. Software instruction set (including specific instructions like string instructions, repeat, segment override, lock prefizers and their use) and Assembly Language programming with the same. Brief overview of some other microprocessors (eg. 6800 Microprocessor).cessors (eg. 6800 Microprocessor).

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Biocomputers Design Lab 1. 3 cr. hrs.

Hands-on experience in software design and validation, microprocessors, computer architecture, real-time computing, embedded software, graphical user interface and networking. An emphasis on medical devices with embedded software and hardware.

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Biocomputers Design Lab 2. 3 cr. hrs.

Continuation of BIEN 4280 with emphasis on high performance computing in workstation environments.

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Biomedical Circuits and Electronics. 4 cr. hrs.

An experience in electrical circuits (AC and DC), electronic devices (Junction, Transistor, Operational, Amplifier) bridges, digital circuits and Boolean implementation, combinational and sequential logic, memories. Use of P-Spice software. Analysis and design.

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Electronic Devices and Applications. 4 cr. hrs.

Electronic components are discussed including semiconducting diodes, bipolar junction transistors, field effect transistors, etc. These devices will be analyzed from their terminal characteristics and their behavior in representative electronic circuits. Applications for devices include simple power supply analysis and design, class A amplifier analysis including transistor biasing and stability analysis, simple digital logic gates, etc.

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Biomedical Instrumentation Design. 4 cr. hrs.

Problems in instrumentation relating to physiological measurements in the laboratory and clinic. Electronic devices for stimulus as well as measurement of physiological quantities. Design of actual instruments. Features include mechanical design, accessory design and safety requirements.

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Artificial Organs. 3 cr. hrs.

Analysis and design of replacements for the heart, kidneys, and lungs. Specification and realization of structures for artificial organ systems. Understand the individual and synergistic function of the major natural ("internal") organs. Understand the major organ replacement systems currently available. Understand the opportunities for, and the major problems associated with, replacing failed organs Cardiovascular system Renal system Pulmonary system (Lung disease; heart-lung bypass) Hepatic system Endocrine system Neural prostheses (Muscular-skeletal prostheses) Identify basic engineering approaches to organ replacement: Functional specification; Locational issues; Device-organism interface (impedance matching); blood access; alternatives to blood Temporal activity --intermittency and control; Energy issues; Biocompatibility and bioactivity Materials: Functional specifications Hemocompatibility Biocompatibility Hybrid system materials Design approaches: Conceptual specification Initial modeling (multi-scale approaches) Modeling during development; Allowance for subject variability Manufacturing Issues: Cleanliness, particle elimination Sterilization Smart packaging Regulatory (FDA) concerns: Animal testing Clinical testing . Specific systems to be studied in detail: Blood vessel replacements; ventricular assist devices; cardiopulmonary bypass systems; hemodialysis systems. Specific engineering/physical chemical concepts to be reviewed and applied: Convective and diffusive transport; phase and ligand-solution equilibria; serial rate processes; transport-coupled enzyme kinetics.

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